دکتر محمدرضا عباس زادگان

دکترای تخصصی ژنتیک پزشکی، استاد تمام ژنتیک پزشکی دانشگاه علوم پزشكي مشهد

مؤسس آزمایشگاه پردیس حافظ، مسئول فنی آزمایشگاه پردیس

آدرس محل کار:

۱) مشهد، آزمایشگاه پردیس
۲) مشهد، پلی کلینیک تخصصی آفرینش نسل مانا
۳) مشهد، پردیس دانشگاه فردوسی، دانشکده پزشکی، گروه ژنتیک پزشکی

راه‌های ارتباطی:

آدرس ایمیل: AbbaszadeganMr@Pardislab.com
تلفن: ۳۷۷۰-۰۵۱

تحصیلات دانشگاهی

  • ۸/۹۰-۵/۹۵  Ph.D. in Medical Genetics – Cancer Genetics
  • University of Arizona Medical Center, Tucson, Arizona 85721
  • Minor: Microbiology & Immunology
  • Major Advisor: William S. Dalton, M.D., Ph.D.
  • Dissertation: Molecular Mechanisms of Drug Resistance in Human Malignancies.
  • ۱/۸۷-۱۲/۹۰ Master of Science in Applied Microbiology
  • Northern Arizona University, Flagstaff, Arizona 86011
  • Major Advisor: Emmanuel T. Akporiaye, Ph.D.
  • Thesis: Tumoricidal Activity of Tumor Infiltrating T-lymphocytes Against EMT6 (mammary carcinoma) Tumor Cells, Following the Injection of Viable or Irradiated Tumor Cells
  • ۹/۸۱-۶/۸۵ Bachelor of Science in Microbiology/Medical Technology
  • University of Montana, Missoula, Montana 59801

۱ تجربیات حرفه ای:

  • ۸/۰۹-۷/۱۰ Adjunct Faculty at TGen and The Arizona State University (Sabbatical), The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, Director: Jeff Trent, Ph.D.
  • ۷/۰۳- ۱۰/۰۳ Fellowship –Diagnosis of Rare Genetic Diseases & their Prenatal Genetic Diagnosis, GeneDx, Inc. DNA Diagnostic Institute affiliated with NIH, Director: Sherri Bale, Ph.D., FABCG.
  • ۱/۹۸- ۱/۲۰۰۰ Fellowship – Clinical Molecular Genetics, The American Board of Medical Genetics
  • NIH/ Georgetown / Children’s Medical Center Joint fellowship program
  • Program Director: Clair A. Francomano, M.D.
  • ۶/۹۵- ۱۱/۹۷ Postdoctoral Fellow-Intramural Research Training Award (IRTA)
  • Diagnostic Development Branch
  • National Human Genome Research Institute, NIH, Bethesda, Maryland 20892
  • Advisor: Mark R. Hughes, M.D., Ph.D.
  • Project: Research and Development of new diagnostic assays for human genetic
  • diseases, Prenatal genetic diagnosis & Familial Breast Cancer
  • ۷/۸۵-۸/۸۶  Medical Technology Internship Program
  • Bannock Regional Medical Center, Pocatello, Idaho 83204
  • Certificates: American Society of Clinical Pathologist (ASCP) & National Certifying Agency (NCA)

۲ مسئولیت اجرایی:

  • رئیس مرکز تحقیقات ژنتیک پزشکی، دانشگاه علوم پزشکی مشهد  از ابتدای تاسیس ۱۳۹۳ تا کنون
  • رئیس پژوهشکده بوعلی، دانشگاه علوم پزشکی مشهد
  • استاد مدعو در دانشگاه ایالتی آریزونا و دانشگاه جورج میسون
  • انتشار بیش از ۲۲۰ مقاله در مجلات علمی معتبر داخلی و خارجی

  • تجربیات آموزشی:

    Medical Genetics, Genetic Counseling Training Courses, Molecular and Cellular Biology, NIH training courses for summer students and fellows, Laboratory Sciences, Immunobiology, General Biology, and Bacteriology

  • فعالیتهای پژوهشی:

    Cancer Genetics:

    • Clinical evaluation of Adjuvant Immunogen therapy with dendritic cells loaded with Total mRNA autologous tumor, in patients with gastric cancer (ستاد سلولهای بنیادی ریاست جمهوری)
    • Investigating the expression level of circulating miR-143 and miR-145 in colorectal cancer patients as a predictor of response to chemotherapy
    • Investigating the efficiency of mutated K-RAS gene deletion in colorectal cancer cells by exosomes carrying CRISPER/Cas9 (صندوق حمایت از پژوهشگران، ریاست جمهوری)
    • Evaluation of mutated K-RAS level in extracted exosomes from plasma of colorectal cancer patients in early stages of disease.
    • Preparation of DC-mRNA vaccine for treatment of Esophageal Squamous Cell Carcinoma (ESCC) patients (Joint Approval by Digestive Disease Research Center, Tehran University of Medical Sciences & MUMS research council).
    • Evaluation of cancer testis antigen expression profile in patients with gastric cancer to introduce specific tumor markers.
    • Expression of CKAP2 and EPHA10 in non-hereditary colorectal cancer patients and their correlation with clinicopathological features.
    • Evaluation of exfoliative cytology and new serum biomarkers in screening of ESCC (Approved by national medical research council).Identification of potentially pathogenic and prognostic genes and pathways associated with esophageal squamous cell carcinoma progression using RNA-seq data from GEO and TCGA databases.
    • Evaluation of GST1 polymorphisms as biomarkers in screening of ESCC.
    • Evaluation of Long DNA and BAT-26 Markers in detection of colorectal cancer (CRC) by molecular analysis of patient’s stool DNA in comparison with normal subjects.
    • Evaluation of frequency of changes in P14 & P16 genes in CRC patients.
    • Prognostic Significance of Germ-line E-Cadherin Mutation in Familial Gastric Cancer.
    • Molecular analysis of Wnt signaling pathway in Gastric cancer.
    • Microsatellite analysis in CRC patients.
    • Study of the association of HPV infection and P53 mutation with ESCC.
    • Microsatellite markers analysis in endometrial & ovarian cancer.
    • Assessment of P53 mutation in pathological staging and surgical margins in squamous cell carcinoma of the head and neck.

    Medical Genetics:

    • CRISPR/Cas9 gene editing in human hematopoitic stemcells isolated from Beta- thalassemia patient-(طرح مصوب نیماد)
    • Beta-thalassemia gene therapy including beta-globin gene addition, or induction of gamma globin based on the CRISPR/Cas system in hematopoietic stem cells: comparison of efficacy and safety of these approaches.
    • Molecular Analysis of CYP21A2 gene in 21-hydroxylase deficiency and CYP11B in 11-hydroxylase deficiency in congenital adrenal hyperplasia patients in Iran.
    • Genetic and clinical study of children with familial Mediterranean fever in northeastern Iran.
    • Friedreich Ataxia: Molecular detection of FRDA GAA repeats in proband from a family in province of Khorasan.
    • Preimplantation Genetics Diagnosis of b- thalassemia using single cell PCR techniques.
    • Carrier detection and prenatal diagnosis of Hemophilia A and Finding of their Common mutation by Molecular Genetics in Khorasan province
    • Mutation detection of TCIRG1 Gene in patients with osteopetrosis by PCR & RT-PCR.
    • Evaluation of HTLV-I tax polymorphism as a probable risk factor for HAM/TSP in Khorasanian patients.Designing, production and evalution of HTLVI, II diagnostic kit for detection of antibody against HTLV virus using HTLV recombinant Envelope proteins.

  1. ژنتیک سرطان – بررسی بیومارکرهای تشخیصی و پیش آگهی

  2. ژنتیک سرطان – درمان های هدفمند مولکولی با siRNA و DC-therapy

  3. ژنتیک سرطان – بررسی Epigenetic در سرطان Colorectal

  4. ژن درمانی و اصلاح ژن با استفاده از CRSPR/Cas9 در بیماریهای تک ژنی

  1. American Society of Human Genetics

  2. American Association for the Advancement of Science

  3. Associate Member, American Association for Cancer Research

  4. Student/Fellow Member, American Society for Microbiology

  5. American Society of Medical Technologists

  6. The Academy of Medical Sciences, I.R. of IRAN(فرهنگستان علوم پزشکی ایران از سال ۱۳۸۴)       

  • کاست ژنی آنزیم ترانسپوزاز SB100 زیبای خفته Sleeping beautyبا استفاده از پروموتر اختصاصی سلولهای سنگفرشی مری
  • فرآیند جداسازی و شناسایی سلول های بنیادی سرطانی از بیماران مبتلا به سرطان معده برای ایمونوتراپی
  • مولکول کایمر چندگانه از آنتی ژنهای کانسر تستیسی برای ایمونوژن تراپی کارسینومای سلول سنگفرشی مری
  • GenBank new sequence submissions:

    Homo sapiens perforin gene, intron 1 (AY489286.1)

    Human T-lymphotropic virus 1 isolate MTA-1 from Iran truncated envelope glycoprotein gene, partial cds (DQ911752.1)

    Homo sapiens isolate patient 1 steroid 21-hydroxylase (CYP21A2) gene, exons 9, 10 and partial cds. (EU236681)

    Homo sapiens isolate patient 2 steroid 21-hydroxylase (CYP21A2) gene, exons 9, 10 and partial cds. (EU236682)

    Homo sapiens mitochondrial 11beta-hydroxylase (CYP11B1) gene, exons 7, 8 and partial cds; nuclear gene for mitochondrial product.(EU236683)

    Homo sapiens adenomatous polyposis coli gene, partial cds. (EU681189)

    Homo sapiens beta-catenin gene, partial cds.(EU681190)

    Homo sapiens adenomatous polyposis coli gene, partial cds. (EU681276)

    Homo sapiens beta-catenin gene, partial cds. (EU681277)

     Tetraogallus caspius isolate CS1 cytochrome b (cytb) gene, partial cds; mitochondrial.(EU106676)

     Homo sapiens potassium channel inwardly rectifing subfamily J member 11 (KCNJ11) gene, complete cds (GU170814.1).

     Homo sapiens truncated mitochondrial cytochrome P450 11B1 (CYP11B1) gene, exon 2 and partial cds; nuclear gene for mitochondrial product (GU201906.1)

  1. ۶/۱۹۸۸ -Sigma Xi, the Scientific Research Society

  2. ۶/۱۹۹۵  -National Institute of Health Intramural Research Training Award (IRTA)

  3. ۳/۱۹۹۶          -NIH Fellows Award for Research Excellence

  4. ۱۲/۲۰۰۵- Khwarizmi First Award for Applied Medical Protocols (Congenital Adrenal Hyperplasia)

  5. ۲۰۱۳   ۳rd rank of the 19th Razi research festival on medical sciences

دکتر محمدرضا عباس زادگان

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